MP 6407: Radiation Biology and Oncology

 

Credit Hours:3-0-3
Prerequisites:Concurrency with NRE 6756 Radiation Physics
Catalog Description:Radiation lesions and repair, mechanisms of cell death, cell cycle effect, radiation sensitizers and protectors, tumor radiobiology, relative sensitivities of human tissues, and radiation carcinogenesis.
Textbooks:Eric J. Hall, Radiobiology for the Radiologist, 5th Edition, Lippincott, Williams and Wilkins, 2000.
Instructors:Chris Wang
Topics:
  1. Radiation Injury and repair
    1. Radiation chemistry of water
    2. Structure of DNA and chromatin and chromosome
    3. Radiation-induced lesions
    4. Excision repair
    5. Repair of DNA/chromosome damage
  2. Survival Curve Theory
    1. Target theory
    2. Survival curve models
  3. Mechanisms of Cell Death
    1. Apoptosis
    2. Reproductive cell death
  4. Cell Cycle Effect
    1. Cell kinetics and cycle phases
    2. Radiosensitivity on cell cycle phases
  5. Modifiers of Radiation Response
    1. Oxygen effect and other radiosensitizers
    2. Radioprotectors
  6. Relative radiation sensitivities of human tissues
  7. Tumor kinetics and Radiobiology
    1. The growth fraction and cell loss from tumors
    2. Basic tumor structure and physiology
    3. Hypoxic cells and reoxygenation in tumors
  8. Radiation Pathology
    1. Acute and late responding normal tissues
    2. General morphology of radiation injury
    3. Acute radiation syndromes
    4. Morphologic changes in irradiated tumors
  9. Radiation Carcinogenesis
    1. Proto-oncogenes and tumor-suppressor genes
    2. Signal transduction and cell-cycle control
    3. Multi-stage carcinogenesis